Tetrandrine Increases the Sensitivity of Human Lung Adenocarcinoma PC14 Cells to Gefitinib by Lysosomal Inhibition.
Identifieur interne : 000375 ( Main/Exploration ); précédent : 000374; suivant : 000376Tetrandrine Increases the Sensitivity of Human Lung Adenocarcinoma PC14 Cells to Gefitinib by Lysosomal Inhibition.
Auteurs : Eiko Sato [Japon] ; Sinya Ohta [Japon] ; Kenjiro Kawakami [Japon] ; Mana Ikeda [Japon] ; Tatsuo Takahashi [Japon] ; Shinjiro Kobayashi [Japon] ; Masaaki Nomura [Japon]Source :
- Anticancer research [ 1791-7530 ] ; 2019.
Descripteurs français
- KwdFr :
- Autophagie, Benzylisoquinoléines (), Benzylisoquinoléines (pharmacologie), Humains, Lignée cellulaire tumorale, Lysosomes (), Lysosomes (métabolisme), Prolifération cellulaire (), Protéines associées aux microtubules (génétique), Protéines associées aux microtubules (métabolisme), Récepteurs ErbB (génétique), Régulation de l'expression des gènes tumoraux (), Résistance aux médicaments antinéoplasiques (), Survie cellulaire (), Synergie des médicaments, Tumeurs du poumon (génétique), Tumeurs du poumon (métabolisme), Tumeurs du poumon (traitement médicamenteux).
- MESH :
- génétique : Protéines associées aux microtubules, Récepteurs ErbB, Tumeurs du poumon.
- métabolisme : Lysosomes, Protéines associées aux microtubules, Tumeurs du poumon.
- pharmacologie : Benzylisoquinoléines.
- traitement médicamenteux : Tumeurs du poumon.
- Autophagie, Benzylisoquinoléines, Humains, Lignée cellulaire tumorale, Lysosomes, Prolifération cellulaire, Régulation de l'expression des gènes tumoraux, Résistance aux médicaments antinéoplasiques, Survie cellulaire, Synergie des médicaments.
English descriptors
- KwdEn :
- Adenocarcinoma of Lung (drug therapy), Adenocarcinoma of Lung (genetics), Adenocarcinoma of Lung (metabolism), Autophagy, Benzylisoquinolines (chemistry), Benzylisoquinolines (pharmacology), Cell Line, Tumor, Cell Proliferation (drug effects), Cell Survival (drug effects), Drug Resistance, Neoplasm (drug effects), Drug Synergism, ErbB Receptors (genetics), Gefitinib (chemistry), Gefitinib (pharmacology), Gene Expression Regulation, Neoplastic (drug effects), Humans, Lung Neoplasms (drug therapy), Lung Neoplasms (genetics), Lung Neoplasms (metabolism), Lysosomes (drug effects), Lysosomes (metabolism), Microtubule-Associated Proteins (genetics), Microtubule-Associated Proteins (metabolism).
- MESH :
- chemical , chemistry : Benzylisoquinolines, Gefitinib.
- drug effects : Cell Proliferation, Cell Survival, Drug Resistance, Neoplasm, Gene Expression Regulation, Neoplastic, Lysosomes.
- drug therapy : Adenocarcinoma of Lung, Lung Neoplasms.
- genetics : Adenocarcinoma of Lung, ErbB Receptors, Lung Neoplasms, Microtubule-Associated Proteins.
- metabolism : Adenocarcinoma of Lung, Lung Neoplasms, Lysosomes, Microtubule-Associated Proteins.
- chemical , pharmacology : Benzylisoquinolines, Gefitinib.
- Autophagy, Cell Line, Tumor, Drug Synergism, Humans.
Abstract
Human lung adenocarcinoma PC14 cells without mutations in the epidermal growth factor receptor (EGFR) are less sensitive to gefitinib than PC9 cells with EGFR mutations. We report the involvement of tetrandrine in autophagy flux as a mechanism that enhances the sensitivity of PC14 cells to gefitinib.
DOI: 10.21873/anticanres.13874
PubMed: 31810924
Affiliations:
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Le document en format XML
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Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Faculty of Pharmaceutical Sciences, Hokuriku University, Kanazawa</wicri:regionArea><wicri:noRegion>Kanazawa</wicri:noRegion></affiliation></author><author><name sortKey="Ohta, Sinya" sort="Ohta, Sinya" uniqKey="Ohta S" first="Sinya" last="Ohta">Sinya Ohta</name><affiliation wicri:level="1"><nlm:affiliation>Faculty of Pharmaceutical Sciences, Hokuriku University, Kanazawa, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Faculty of Pharmaceutical Sciences, Hokuriku University, Kanazawa</wicri:regionArea><wicri:noRegion>Kanazawa</wicri:noRegion></affiliation></author><author><name sortKey="Kawakami, Kenjiro" sort="Kawakami, Kenjiro" uniqKey="Kawakami K" first="Kenjiro" last="Kawakami">Kenjiro Kawakami</name><affiliation wicri:level="1"><nlm:affiliation>Faculty of Pharmaceutical Sciences, Hokuriku University, Kanazawa, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Faculty of Pharmaceutical Sciences, Hokuriku University, Kanazawa</wicri:regionArea><wicri:noRegion>Kanazawa</wicri:noRegion></affiliation></author><author><name sortKey="Ikeda, Mana" sort="Ikeda, Mana" uniqKey="Ikeda M" first="Mana" last="Ikeda">Mana Ikeda</name><affiliation wicri:level="1"><nlm:affiliation>Faculty of Pharmaceutical Sciences, Hokuriku University, Kanazawa, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Faculty of Pharmaceutical Sciences, Hokuriku University, Kanazawa</wicri:regionArea><wicri:noRegion>Kanazawa</wicri:noRegion></affiliation></author><author><name sortKey="Takahashi, Tatsuo" sort="Takahashi, Tatsuo" uniqKey="Takahashi T" first="Tatsuo" last="Takahashi">Tatsuo Takahashi</name><affiliation wicri:level="1"><nlm:affiliation>Faculty of Pharmaceutical Sciences, Hokuriku University, Kanazawa, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Faculty of 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Pharmaceutical Sciences, Hokuriku University, Kanazawa</wicri:regionArea><wicri:noRegion>Kanazawa</wicri:noRegion></affiliation></author></analytic><series><title level="j">Anticancer research</title><idno type="eISSN">1791-7530</idno><imprint><date when="2019" type="published">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adenocarcinoma of Lung (drug therapy)</term><term>Adenocarcinoma of Lung (genetics)</term><term>Adenocarcinoma of Lung (metabolism)</term><term>Autophagy</term><term>Benzylisoquinolines (chemistry)</term><term>Benzylisoquinolines (pharmacology)</term><term>Cell Line, Tumor</term><term>Cell Proliferation (drug effects)</term><term>Cell Survival (drug effects)</term><term>Drug Resistance, Neoplasm (drug effects)</term><term>Drug Synergism</term><term>ErbB Receptors (genetics)</term><term>Gefitinib (chemistry)</term><term>Gefitinib (pharmacology)</term><term>Gene Expression Regulation, Neoplastic (drug effects)</term><term>Humans</term><term>Lung Neoplasms (drug therapy)</term><term>Lung Neoplasms (genetics)</term><term>Lung Neoplasms (metabolism)</term><term>Lysosomes (drug effects)</term><term>Lysosomes (metabolism)</term><term>Microtubule-Associated Proteins (genetics)</term><term>Microtubule-Associated Proteins (metabolism)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Autophagie</term><term>Benzylisoquinoléines ()</term><term>Benzylisoquinoléines (pharmacologie)</term><term>Humains</term><term>Lignée cellulaire tumorale</term><term>Lysosomes ()</term><term>Lysosomes (métabolisme)</term><term>Prolifération cellulaire ()</term><term>Protéines associées aux microtubules (génétique)</term><term>Protéines associées aux microtubules (métabolisme)</term><term>Récepteurs ErbB (génétique)</term><term>Régulation de l'expression des gènes tumoraux ()</term><term>Résistance aux médicaments antinéoplasiques ()</term><term>Survie cellulaire ()</term><term>Synergie des médicaments</term><term>Tumeurs du poumon (génétique)</term><term>Tumeurs du poumon (métabolisme)</term><term>Tumeurs du poumon (traitement médicamenteux)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Benzylisoquinolines</term><term>Gefitinib</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Cell Proliferation</term><term>Cell Survival</term><term>Drug Resistance, Neoplasm</term><term>Gene Expression Regulation, Neoplastic</term><term>Lysosomes</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Adenocarcinoma of Lung</term><term>Lung Neoplasms</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Adenocarcinoma of Lung</term><term>ErbB Receptors</term><term>Lung Neoplasms</term><term>Microtubule-Associated Proteins</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Protéines associées aux microtubules</term><term>Récepteurs ErbB</term><term>Tumeurs du poumon</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Adenocarcinoma of Lung</term><term>Lung Neoplasms</term><term>Lysosomes</term><term>Microtubule-Associated Proteins</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Lysosomes</term><term>Protéines associées aux microtubules</term><term>Tumeurs du poumon</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Benzylisoquinoléines</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Benzylisoquinolines</term><term>Gefitinib</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Tumeurs du poumon</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Autophagy</term><term>Cell Line, Tumor</term><term>Drug Synergism</term><term>Humans</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Autophagie</term><term>Benzylisoquinoléines</term><term>Humains</term><term>Lignée cellulaire tumorale</term><term>Lysosomes</term><term>Prolifération cellulaire</term><term>Régulation de l'expression des gènes tumoraux</term><term>Résistance aux médicaments antinéoplasiques</term><term>Survie cellulaire</term><term>Synergie des médicaments</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Human lung adenocarcinoma PC14 cells without mutations in the epidermal growth factor receptor (EGFR) are less sensitive to gefitinib than PC9 cells with EGFR mutations. We report the involvement of tetrandrine in autophagy flux as a mechanism that enhances the sensitivity of PC14 cells to gefitinib.</div></front></TEI><affiliations><list><country><li>Japon</li></country></list><tree><country name="Japon"><noRegion><name sortKey="Sato, Eiko" sort="Sato, Eiko" uniqKey="Sato E" first="Eiko" last="Sato">Eiko Sato</name></noRegion><name sortKey="Ikeda, Mana" sort="Ikeda, Mana" uniqKey="Ikeda M" first="Mana" last="Ikeda">Mana Ikeda</name><name sortKey="Kawakami, Kenjiro" sort="Kawakami, Kenjiro" uniqKey="Kawakami K" first="Kenjiro" last="Kawakami">Kenjiro Kawakami</name><name sortKey="Kobayashi, Shinjiro" sort="Kobayashi, Shinjiro" uniqKey="Kobayashi S" first="Shinjiro" last="Kobayashi">Shinjiro Kobayashi</name><name sortKey="Nomura, Masaaki" sort="Nomura, Masaaki" uniqKey="Nomura M" first="Masaaki" last="Nomura">Masaaki Nomura</name><name sortKey="Ohta, Sinya" sort="Ohta, Sinya" uniqKey="Ohta S" first="Sinya" last="Ohta">Sinya Ohta</name><name sortKey="Takahashi, Tatsuo" sort="Takahashi, Tatsuo" uniqKey="Takahashi T" first="Tatsuo" last="Takahashi">Tatsuo Takahashi</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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